Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast.
Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly worse recurrent-free survival than other patients.
Additionally, Claudin-8 has been suggested as a sensitive marker for oncocytomas. In one study, the majority of oncocytomas (92%) had moderate to strong staining, which differentiated it from papillary (14%), clear cell (12%) and chromophobe (0%) renal cell carcinomas.
Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast.
Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly worse recurrent-free survival than other patients.
Additionally, Claudin-8 has been suggested as a sensitive marker for oncocytomas. In one study, the majority of oncocytomas (92%) had moderate to strong staining, which differentiated it from papillary (14%), clear cell (12%) and chromophobe (0%) renal cell carcinomas.
Claudins are a large family of tight junction proteins that regulate cellular adhesion, polarity and glandular differentiation. Claudin-8 is one of the 24 member family known to exist in humans, with each having its tissue specific expression. Claudin-8 expression has been demonstrated in multiple organs, presenting a membranous and cytoplasmic staining pattern in the distal convoluted tubules and collecting ducts of the kidney, and apicolateral staining of luminal cells in the breast.
Disruption of tight junctions is believed to be one of the processes that occur in carcinogenesis that allows for the loss of cellular cohesion, aggressive growth, and de-differentiation of cancer cells. Studies have shown down regulation in Claudin-8 expression in intra- and extrahepatic bile duct cancer, gallbladder carcinoma, colorectal carcinoma and invasive ductal carcinoma. A study measuring expression levels of multiple claudins revealed that claudin-low breast cancer patients had significantly worse recurrent-free survival than other patients.
Additionally, Claudin-8 has been suggested as a sensitive marker for oncocytomas. In one study, the majority of oncocytomas (92%) had moderate to strong staining, which differentiated it from papillary (14%), clear cell (12%) and chromophobe (0%) renal cell carcinomas.
