LSP1 (leukocyte-specific protein 1) is an intracellular F-actin binding protein. This protein may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. LSP1 is expressed in lymphocytes, macrophages, and neutrophils. It is a specific marker of human leukocytes. The LSP1 protein was detected in a wide range of leukemias and lymphomas, particularly of B-cell origin, and in tumor cells in classical Hodgkin's disease. In combination with PU.1, LSP1 may be useful in differentiating T-cell-rich B-cell lymphoma (LSP1+, PU.1-) from lymphocyte-predominant Hodgkin's disease (LSP1-, PU.1 expression variable).
Literature:
Manufacturer site:
LSP1 (EP164)
Rabbit Monoclonal
LSP1 (leukocyte-specific protein 1) is an intracellular F-actin binding protein. This protein may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. LSP1 is expressed in lymphocytes, macrophages, and neutrophils. It is a specific marker of human leukocytes. The LSP1 protein was detected in a wide range of leukemias and lymphomas, particularly of B-cell origin, and in tumor cells in classical Hodgkin's disease. In combination with PU.1, LSP1 may be useful in differentiating T-cell-rich B-cell lymphoma (LSP1+, PU.1-) from lymphocyte-predominant Hodgkin's disease (LSP1-, PU.1 expression variable).
Rabbit Monoclonal
LSP1 (leukocyte-specific protein 1) is an intracellular F-actin binding protein. This protein may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. LSP1 is expressed in lymphocytes, macrophages, and neutrophils. It is a specific marker of human leukocytes. The LSP1 protein was detected in a wide range of leukemias and lymphomas, particularly of B-cell origin, and in tumor cells in classical Hodgkin's disease. In combination with PU.1, LSP1 may be useful in differentiating T-cell-rich B-cell lymphoma (LSP1+, PU.1-) from lymphocyte-predominant Hodgkin's disease (LSP1-, PU.1 expression variable).
