CD1a is a non-polymorphic major histocompatibitity complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with ß-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node.
Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X)2, a subset of T-lymphoblastic lymphoma/leukemia. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms.
CD1a is a non-polymorphic major histocompatibitity complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with ß-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node.
Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X)2, a subset of T-lymphoblastic lymphoma/leukemia. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms.
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CD1a is a non-polymorphic major histocompatibitity complex class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with ß-microglobulin. In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating dendritic cells, and rare antigen-presenting cells of the lymph node.
Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X)2, a subset of T-lymphoblastic lymphoma/leukemia. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms.
