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You searched for: NKX3.1 (EP356)
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NKX3.1 (EP356)

Rabbit Monoclonal

NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8.1-3 It is difficult to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma using hematoxylin and eosin stained specimens.2 Current prostate adenocarcinoma markers such as PSA and PSAP are very useful in determining prostate origin of prostate cancer in other sites, but have lower sensitivity when identifying poorly differentiated compared to well differentiated cases.2 Currently, thrombomodulin and uroplakin are used to identify tumors of urothelial origin; however, their sensitivities are suboptimal.2 In a study by Gurel et al., nearly all cases of metastatic prostate adenocarcinoma were stained by NKX3.1.1 NKX3.1-positive prostate carcinoma cells exhibit nuclear staining.1In another study conducted by Chuang et al., nearly all cases of urothelial carcinoma were negative for NKX3.12 Lastly, NKX3.1 has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast.3 NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC.32 NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.1-2

1. Gurel B, et al. NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol. 2010; 34:1097-1105.

2. Chuang A, et al. Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma. Am J Clin Pathol. 2007; 31:1246-55.

3. Asch-Kendrick R, et al. NKX3.1 is expressed in ER-positive and AR-positive primary breast carcinomas. J Clin Pathol. 2014; 67:768-71.

Item No.DescriptionQuantityPrice
CMQ-441R10
NKX3.1 Rabbit EP356 25mL Predilute // NKX3.1 lapin EP356 25mL prédiluéLogin to see pricing
CMQ-441R14
NKX3.1 Rabbit EP356 0.1mL Concentrate/EA // NKX3.1 lapin EP356 0.1mL concentré, unitéLogin to see pricing
CMQ-441R15
NKX3.1 Rabbit EP356 0.5mL Concentrate/EA // NKX3.1 lapin EP356 0.5mL concentré, unitéLogin to see pricing
CMQ-441R16
NKX3.1 Rabbit EP356 1mL Concentrate/EA // NKX3.1 lapin EP356 1mL concentré, unitéLogin to see pricing
CMQ-441R17
NKX3.1 Rabbit EP356 1mL Predilute/EA // NKX3.1 lapin EP356 1mL prédilué, unitéLogin to see pricing
CMQ-441R18
NKX3.1 Rabbit EP356 7mL Predilute /EA // NKX3.1 Rabbit EP356 7mL prédilué, unitéLogin to see pricing