Heterogeneous nucleus ribonucleoprotein (hnRNP) K is a component of the hnRNP complex, encoding for a 464 amino acid protein that mediates DNA and RNA binding. It is involved in the transcription, splicing and translation processes and recently implicated in tumorigenesis. Several oncogenes, such as c-Src, eIF4E and c-myc are regulated by hnRNP K. Correlation between elevated expression of hnRNP K and tumor development and progression are well documented. It has also been found to enhance cell proliferation and neoplastic transformation.
In normal tissues, hnRNP K is present primarily in the nucleus. Nuclear and aberrant cytoplasmic overexpression have been described in colorectal, prostate, hepatic, esophageal, and breast cancers that have been significantly associated with poor prognosis.
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hnRNP K (EP330)
Rabbit Monoclonal
Heterogeneous nucleus ribonucleoprotein (hnRNP) K is a component of the hnRNP complex, encoding for a 464 amino acid protein that mediates DNA and RNA binding. It is involved in the transcription, splicing and translation processes and recently implicated in tumorigenesis. Several oncogenes, such as c-Src, eIF4E and c-myc are regulated by hnRNP K. Correlation between elevated expression of hnRNP K and tumor development and progression are well documented. It has also been found to enhance cell proliferation and neoplastic transformation.
In normal tissues, hnRNP K is present primarily in the nucleus. Nuclear and aberrant cytoplasmic overexpression have been described in colorectal, prostate, hepatic, esophageal, and breast cancers that have been significantly associated with poor prognosis.
Rabbit Monoclonal
Heterogeneous nucleus ribonucleoprotein (hnRNP) K is a component of the hnRNP complex, encoding for a 464 amino acid protein that mediates DNA and RNA binding. It is involved in the transcription, splicing and translation processes and recently implicated in tumorigenesis. Several oncogenes, such as c-Src, eIF4E and c-myc are regulated by hnRNP K. Correlation between elevated expression of hnRNP K and tumor development and progression are well documented. It has also been found to enhance cell proliferation and neoplastic transformation.
In normal tissues, hnRNP K is present primarily in the nucleus. Nuclear and aberrant cytoplasmic overexpression have been described in colorectal, prostate, hepatic, esophageal, and breast cancers that have been significantly associated with poor prognosis.
