Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Anti-somatostatin is a useful marker of D-cells of pancreatic islet cells.1-2 D-cells identification can be used to identify hyperplasia of the pancreatic islets of Langerhans and tumors arising from these cells. Anti-somatostatin recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet cells originating in pancreatic ductules.3-6
1. Krejs GJ. Physiological role of somatostatin in the digestive tract: gastric acid secretion, intestinal absorption, and motility. Scand J Gastroenterol Suppl. 1986; 119:47-53.
2. Tzaneva MA. Ultrastructural immunohistochemical localization of gastrin, somatostatin and serotonin in endocrine cells of human antral gastric mucosa. Acta Histochem. 2003; 105:191-201.
3. Krejs GJ, et al. Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Eng J Med. 1979; 301:285-92.
4. Friesen, SR. Tumors of the endocrine pancreas. N Eng J Med. 1982; 306:580-90.
5. Kanavaros P, et al. Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case. Histol Histopathol. 1990; 5:325-8.
6. Chejfec G, et al. Neuroendocrine carcinoma of the stomach with extensive somatostatin immunoreactivity. Ultrastruct Pathol. 1992; 16:537-45.
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Somatostatin (EP130)
Rabbit Monoclonal
Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Anti-somatostatin is a useful marker of D-cells of pancreatic islet cells.1-2 D-cells identification can be used to identify hyperplasia of the pancreatic islets of Langerhans and tumors arising from these cells. Anti-somatostatin recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet cells originating in pancreatic ductules.3-6
1. Krejs GJ. Physiological role of somatostatin in the digestive tract: gastric acid secretion, intestinal absorption, and motility. Scand J Gastroenterol Suppl. 1986; 119:47-53.
2. Tzaneva MA. Ultrastructural immunohistochemical localization of gastrin, somatostatin and serotonin in endocrine cells of human antral gastric mucosa. Acta Histochem. 2003; 105:191-201.
3. Krejs GJ, et al. Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Eng J Med. 1979; 301:285-92.
4. Friesen, SR. Tumors of the endocrine pancreas. N Eng J Med. 1982; 306:580-90.
5. Kanavaros P, et al. Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case. Histol Histopathol. 1990; 5:325-8.
6. Chejfec G, et al. Neuroendocrine carcinoma of the stomach with extensive somatostatin immunoreactivity. Ultrastruct Pathol. 1992; 16:537-45.
Rabbit Monoclonal
Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine cells, thymic endocrine cells, and thyroid C-cells. Anti-somatostatin is a useful marker of D-cells of pancreatic islet cells.1-2 D-cells identification can be used to identify hyperplasia of the pancreatic islets of Langerhans and tumors arising from these cells. Anti-somatostatin recognizes somatostatin-containing cells in pancreatic tumors, islet cell hyperplasia, and islet cells originating in pancreatic ductules.3-6
1. Krejs GJ. Physiological role of somatostatin in the digestive tract: gastric acid secretion, intestinal absorption, and motility. Scand J Gastroenterol Suppl. 1986; 119:47-53.
2. Tzaneva MA. Ultrastructural immunohistochemical localization of gastrin, somatostatin and serotonin in endocrine cells of human antral gastric mucosa. Acta Histochem. 2003; 105:191-201.
3. Krejs GJ, et al. Somatostatinoma syndrome. Biochemical, morphologic and clinical features. N Eng J Med. 1979; 301:285-92.
4. Friesen, SR. Tumors of the endocrine pancreas. N Eng J Med. 1982; 306:580-90.
5. Kanavaros P, et al. Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case. Histol Histopathol. 1990; 5:325-8.
6. Chejfec G, et al. Neuroendocrine carcinoma of the stomach with extensive somatostatin immunoreactivity. Ultrastruct Pathol. 1992; 16:537-45.
